In vivo characterization of [18F]AVT-011 as a radiotracer for PET imaging of multidrug resistance.

Pavitra KannanAndrás FürediSabina DizdarevicThomas WanekSeverin MairingerJeffrey CollinsTheresa FallsR Michael van DamDivya MaheshwariJason T LeeGergely SzakácsOliver Langer

Published in: European journal of nuclear medicine and molecular imaging (2019)

[18F]AVT-011 is a dual ABCB1/ABCG2 substrate radiotracer that can quantify transporter function at the blood-brain barrier and in ABCB1-expressing tumors, making it potentially suitable for clinical imaging of ABCB1-mediated MDR in tumors.

Keyphrases

pet imaging
positron emission tomography
high resolution
multidrug resistant
computed tomography
mass spectrometry
cancer stem cells