The risk of delirium after sedation with propofol or midazolam in intensive care unit patients.
Thomas G van GelderIrene J van Diem-ZaalSandra M A Dijkstra-KerstenNikki de MulArief LalmohamedArjen J C SlooterPublished in: British journal of clinical pharmacology (2024)
This study among sedated ICU patients suggests that, compared to propofol sedation, midazolam sedation is associated with a higher risk of subsequent delirium. This risk seems more apparent in patients with high cumulative midazolam intravenous doses. Our findings underpin the recommendations of the Society of Critical Care Medicine Pain, Agitation/sedation, Delirium, Immobility (rehabilitation/mobilization), and Sleep (disruption) guidelines to use propofol over benzodiazepines for sedation in ICU patients.
Keyphrases
- intensive care unit
- end stage renal disease
- mechanical ventilation
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- cardiac surgery
- magnetic resonance imaging
- physical activity
- low dose
- magnetic resonance
- acute respiratory distress syndrome
- neuropathic pain
- acute kidney injury
- depressive symptoms
- extracorporeal membrane oxygenation
- hip fracture