Recent Advances of Adipose-Tissue-Derived Mesenchymal Stem Cell-Based Therapy for Retinal Diseases.
Lucia FinocchioMarco ZeppieriAndrea GabaiLeopoldo SpadeaCarlo SalatiPublished in: Journal of clinical medicine (2023)
With the rapid development of stem cell research in modern times, stem cell-based therapy has opened a new era of tissue regeneration, becoming one of the most promising strategies for currently untreatable retinal diseases. Among the various sources of stem cells, adipose tissue-derived mesenchymal stem cells (ADSCs) have emerged as a promising therapeutic modality due to their characteristics and multiple functions, which include immunoregulation, anti-apoptosis of neurons, cytokine and growth factor secretion, and antioxidative activities. Studies have shown that ADSCs can facilitate the replacement of dying cells, promote tissue remodeling and regeneration, and support the survival and growth of retinal cells. Recent studies in this field have provided numerous experiments using different preclinical models. The aim of our review is to provide an overview of the therapeutic strategies, modern-day clinical trials, experimental models, and potential clinical use of this fascinating class of cells in addressing retinal disorders and diseases.
Keyphrases
- stem cells
- cell cycle arrest
- induced apoptosis
- adipose tissue
- optical coherence tomography
- growth factor
- diabetic retinopathy
- clinical trial
- cell therapy
- endoplasmic reticulum stress
- cell death
- oxidative stress
- pi k akt
- mesenchymal stem cells
- palliative care
- signaling pathway
- optic nerve
- insulin resistance
- metabolic syndrome
- cell proliferation
- bone marrow
- spinal cord
- human health
- climate change
- smoking cessation
- quantum dots