Hippocampal transcriptome analysis following maternal separation implicates altered RNA processing in a mouse model of fetal alcohol spectrum disorder.
Bonnie L J AlberryChristina A CastellaniShiva M SinghPublished in: Journal of neurodevelopmental disorders (2020)
Together, transcriptional control in the hippocampus is implicated as a potential underlying mechanism leading to anxiety-like behavior via environmental insults. Further research is required to elucidate the mechanism involved and use this insight towards early diagnosis and amelioration strategies involving children born with FASD.
Keyphrases
- spectrum disorder
- mouse model
- human health
- young adults
- cerebral ischemia
- gene expression
- birth weight
- gestational age
- transcription factor
- low birth weight
- sleep quality
- brain injury
- risk assessment
- alcohol consumption
- physical activity
- cognitive impairment
- prefrontal cortex
- oxidative stress
- depressive symptoms
- mass spectrometry
- subarachnoid hemorrhage
- climate change
- heat shock
- heat shock protein