Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease.

Xiaojing ChuMartin JaegerJoep BeumerOlivier B BakkerRaul Aguirre-GamboaMarije OostingSanne P SmeekensSimone MoorlagVera P MouritsValerie A C M KoekenCharlotte de BreeTrees JansenIan T MathewsKhoi DaoMahan NajhawanJeramie D WatrousIrma JoostenSonia SharmaHans J P M KoenenSebo WithoffIris H JonkersRomana T Netea-MaierRamnik J XavierLude FrankeCheng-Jian XuLeo A B JoostenSerena SannaMohit JainVinod KumarHans CleversCisca WijmengaMihai G NeteaYang Li

Published in: Genome biology (2021)

This study provides a comprehensive map of the integration between the blood metabolome and immune phenotypes, reveals novel genetic factors that regulate blood metabolite concentrations, and proposes an integrative approach for identifying new disease treatment targets.

Keyphrases

ms ms
genome wide
copy number
combination therapy
smoking cessation