A Population Pharmacokinetic Model to Predict the Individual Starting Dose of Tacrolimus Following Pediatric Renal Transplantation.

Louise M AndrewsDennis A HesselinkTeun van GelderBirgit C P KochElisabeth A M CornelissenRoger J M BrüggemannRon H N van SchaikSaskia N de WildtKarlien CransbergBrenda C M de Winter

Published in: Clinical pharmacokinetics (2019)

During the first 6 weeks after transplantation, the tacrolimus weight-normalized starting dose should be higher in pediatric kidney transplant recipients with a lower bodyweight, those who express the cytochrome P450 3A5 genotype, and those who receive a kidney from a deceased donor.

Keyphrases

body mass index
physical activity
weight loss
stem cells
weight gain
young adults
gestational age
body weight
childhood cancer
preterm birth