Pilot trial of perampanel on peritumoral hyperexcitability and clinical outcomes in newly diagnosed high-grade glioma.
Steven TobochnikMichael S ReganMaria K C DorotanDustine ReichEmily LapinskasMd Amin HossainSylwia A StopkaSandro SantagataMelissa M MurphyOmar ArnaoutWenya Linda BiE Antonio ChioccaAlexandra J GolbyMichael A MooneyTimothy R SmithKeith L LigonPatrick Y WenNathalie Y R AgarJong Woo LeePublished in: medRxiv : the preprint server for health sciences (2024)
A peri-operative loading regimen of perampanel was safe and well-tolerated, with similar peritumoral hyperexcitability as in levetiracetam-treated patients. Maintenance anti-glutamatergic therapy was not observed to impact survival outcomes.