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Differential modulation of allergic rhinitis nasal transcriptome by dupilumab and allergy immunotherapy.

Matthew F WippermanKaitlyn M GayvertAmanda AtanasioClaire Q WangJonathan CorrenAngelica CovarrubiasIan SetliffErica ChioElizabeth LawsKelley WolfeSivan HarelJennifer MaloneyGary HermanJamie M OrengoWei Keat LimSara C HamonJennifer D HamiltonMeagan P O'Brien
Published in: Allergy (2024)
These results demonstrate type 2 inflammation is an important contributor to the pathophysiology of AR disease and that inhibition of the type 2 pathway with dupilumab may normalize nasal tissue gene expression.
Keyphrases
  • atopic dermatitis
  • gene expression
  • allergic rhinitis
  • dna methylation
  • oxidative stress
  • chronic rhinosinusitis
  • genome wide
  • single cell