Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients.
Csaba KonradHibiki KawamataKirsten G BredvikAndrea J ArreguinSteven A CajamarcaJonathan C HupfJohn M RavitsTimothy M MillerNicholas J MaragakisChadwick M HalesJonathan D GlassSteven GrossHiroshi MitsumotoGiovanni ManfrediPublished in: Molecular neurodegeneration (2017)
sALS, PLS, and C9Orf72 fibroblasts share hypermetabolic features, while presenting differences of bioenergetics. The absence of correlation between energy metabolism activation and ATP levels in sALS and PLS fibroblasts suggests that in these cells hypermetabolism is a mechanism to adapt to energy dissipation. Results from SVM support the use of metabolic characteristics of ALS fibroblasts and multivariate analysis to develop classifiers for patient stratification.