Engineering Quick- and Long-acting Naloxone Delivery Systems for Treating Opioid Overdose.

Farrokh SharifiYazan J MeqbilAndrew OtteAnna M GutridgeArryn T BlaineRichard M van RijnKinam Park

Published in: Pharmaceutical research (2021)

Naloxone released from the three selected formulations could inhibit DAMGO-induced β-arrestin 2 recruitment. This indicates that the proposed naloxone delivery system is adequate for opioid reversal during the naloxone release duration.

Keyphrases

chronic pain
pain management
high glucose
oxidative stress
drug induced