Transport of metformin metabolites by guanidinium exporters of the Small Multidrug Resistance family.

Rachael M LuceroKemal DemirerTrevor Justin Yeh Randy B Stockbridge

Published in: bioRxiv : the preprint server for biology (2023)

Using solid supported membrane electrophysiology, structural biology, and binding assays, we characterize binding and transport of metformin metabolites by bacterial SMR transporters, including proteins associated with horizontal gene transfer in wastewater bacteria that degrade metformin.

Keyphrases

ms ms
dna binding
wastewater treatment
high throughput
binding protein
copy number
dna methylation
anaerobic digestion