Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Supports Hepatocellular Carcinoma Progression.

Meng-Jia SongJunyi HeQiu-Zhong PanJieying YangJingjing ZhaoYao-Jun ZhangYue HuangYan TangQijing WangJia HeJiamei GuYongqiang LiShiping ChenJianxiong ZengZi-Qi ZhouChaopin YangYulong HanHao ChenTong XiangDe-Sheng WengJian-Chuan Xia

Published in: Hepatology (Baltimore, Md.) (2022)

This study reveals a cytokine-mediated cellular crosstalk and clinical network involving the CLCF1-CXCL6/TGF-β axis, which regulates the positive feedback loop among CAFs, tumor stemness, and TANs, HCC progression, and patient prognosis. These results may support the CLCF1 cascade as a potential prognostic biomarker and suggest that selective blockade of CLCF1/ciliary neurotrophic factor receptor or ERK1/2 signaling could provide an effective therapeutic target for patients with HCC.

Keyphrases

stem cells
signaling pathway
epithelial mesenchymal transition
transforming growth factor
cell proliferation
pi k akt
climate change
wound healing