Infections associated with immunotherapeutic and molecular targeted agents in hematology and oncology. A position paper by the European Conference on Infections in Leukemia (ECIL).
Georg MaschmeyerJulien de GreefSibylle C MellinghoffAnnamaria NosariAnne Thiebaut-BertrandAnne BergeronTomas FranquetNicole M A BlijlevensJohan A Maertensnull nullPublished in: Leukemia (2019)
A multitude of new agents for the treatment of hematologic malignancies has been introduced over the past decade. Hematologists, infectious disease specialists, stem cell transplant experts, pulmonologists and radiologists have met within the framework of the European Conference on Infections in Leukemia (ECIL) to provide a critical state-of-the-art on infectious complications associated with immunotherapeutic and molecular targeted agents used in clinical routine. For brentuximab vedotin, blinatumomab, CTLA4- and PD-1/PD-L1-inhibitors as well as for ibrutinib, idelalisib, HDAC inhibitors, mTOR inhibitors, ruxolitinib, and venetoclax, a detailed review of data available until August 2018 has been conducted, and specific recommendations for prophylaxis, diagnostic and differential diagnostic procedures as well as for clinical management have been developed.
Keyphrases
- stem cells
- chronic lymphocytic leukemia
- infectious diseases
- acute myeloid leukemia
- bone marrow
- hodgkin lymphoma
- cancer therapy
- clinical practice
- acute lymphoblastic leukemia
- palliative care
- cell proliferation
- artificial intelligence
- risk factors
- machine learning
- tyrosine kinase
- mesenchymal stem cells
- deep learning
- histone deacetylase
- drug delivery
- replacement therapy
- smoking cessation