STuning Blood-Material Interactions to Generate Versatile Hemostatic Powders And Gels.

Polymer-based hemostatic materials/devices have been increasingly exploited for versatile clinical scenarios, while it is urgently demanded to reveal the rational design/facile approach for procoagulant surfaces through regulating blood-material interactions. In this work, degradable powders (PLPS) and thermo-responsive gels (F127-PLPS) were readily developed as promising hemostatic materials for versatile clinical applications, through tuning blood-material interactions with optimized grafting of cationic polylysine: the former was facilely prepared by conjugating polylysine onto porous starch particle, whilst F127-PLPS was prepared by the simple mixture of PLPS and commercial thermo-sensitive polymer. In vitro and in vivo results demonstrated that PLPS2 with the optimal-/medium content of polylysine grafts achieved the superior hemostatic performance. The underlying procoagulant mechanism of PLPS2 surface was revealed as the selective fibrinogen adsorption among the competitive plasma-protein-adsorption process, which is the foundation of other blood-material interactions. Moreover, in vitro results confirmed the achieved procoagulant surface of F127-PLPS through optimal PLPS2 loading. Together with the tunable thermo-responsiveness, F127-PLPS exhibited outstanding hemostatic utilization in both femoral-artery-injury and renal-artery-embolization models. Our work thereby pioneers an appealing approach for generating versatile polymer-based hemostatic materials/devices. This article is protected by copyright. All rights reserved.