Transcriptional Changes in Kidney Allografts with Histology of Antibody-Mediated Rejection without Anti-HLA Donor-Specific Antibodies.

Jasper CallemeynEvelyne LerutHenriette de LoorIngrid ArijsOlivier ThaunatAlice KoenigVannary Meas-YedidJean-Christophe Olivo-MarinPhilip HalloranJessica ChangLieven ThorrezDirk KuypersBen SprangersLeentje Van LommelFrans SchuitMarie EssigWilfried GwinnerDany AnglicheauPierre MarquetMaarten Naesens

Published in: Journal of the American Society of Nephrology : JASN (2020)

ABMR histology corresponds to a robust intragraft transcriptional signature, irrespective of HLA-DSA status. Outcome after ABMR histology is not solely determined by the histomolecular presentation but is predicted by the underlying etiologic factor. It is important to consider this heterogeneity in further research and in treatment decisions for patients with ABMR histology.

Keyphrases

gene expression
smoking cessation