Insulin resistance induced by de novo pathway-generated C16-ceramide is associated with type 2 diabetes in an obese population.

Shahanas ChathothMona H IsmailHanan M AlghamdiHazem Mohamed ZakariaKhairi Ahmed HassanSaeed AlshomimiChittibabu VatteCyril CyrusHind S AlsaifAhmed MostafaHeba ShaabanAmein Al Ali

Published in: Lipids in health and disease (2022)

The present study indicates that C16-ceramide plays a pivotal role in inducing insulin resistance. Overexpression of SPT1 in the obese-diabetic group and its positive correlation with C16-ceramide suggest that C16-ceramide was generated through the de novo pathway.

Keyphrases

insulin resistance
adipose tissue
type diabetes
metabolic syndrome
high fat diet
weight loss
polycystic ovary syndrome
skeletal muscle
high fat diet induced
cell proliferation
obese patients
transcription factor