Combined Erlotinib and PF-03084014 treatment contributes to synthetic lethality in head and neck squamous cell carcinoma.

Yang ZhengZhao WangXu DingYibo DongWei ZhangWei ZhangYi ZhongWenyi GuYunong WuXiaomeng Song

Published in: Cell proliferation (2017)

These results suggested that concomitant inhibition of the Notch1 and EGFR pathways represented a rational strategy for promoting apoptosis in HNSCC and overcoming treatment resistance.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
oxidative stress
cell proliferation
endoplasmic reticulum stress
tyrosine kinase
advanced non small cell lung cancer
signaling pathway
cell cycle arrest