Prevalence and clinical predictors of inappropriate direct oral anticoagulant dosage in octagenarians with atrial fibrillation.
Andreina CarboneFrancesco SantelliRoberta BottinoEmilio AttenaCarmine MazzoneValentina ParisiAntonello D'AndreaPaolo GolinoGerardo NigroVincenzo RussoPublished in: European journal of clinical pharmacology (2022)
In our analysis, nearly one-third of octogenarians with AF received an inappropriate dose of DOAC. Several clinical factors were associated with DOACs' overdosage (diabetes mellitus type II, previous bleeding) or underdosage (male gender, coronary artery disease, and higher body mass index). Octogenarians with inappropriate DOACs underdosage showed less survival.
Keyphrases
- atrial fibrillation
- direct oral anticoagulants
- body mass index
- coronary artery disease
- venous thromboembolism
- left atrial
- catheter ablation
- oral anticoagulants
- percutaneous coronary intervention
- left atrial appendage
- heart failure
- weight gain
- mental health
- coronary artery bypass grafting
- cardiovascular disease
- metabolic syndrome
- left ventricular
- insulin resistance
- acute coronary syndrome
- free survival
- skeletal muscle
- aortic stenosis