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Prevalence and clinical predictors of inappropriate direct oral anticoagulant dosage in octagenarians with atrial fibrillation.

Andreina CarboneFrancesco SantelliRoberta BottinoEmilio AttenaCarmine MazzoneValentina ParisiAntonello D'AndreaPaolo GolinoGerardo NigroVincenzo Russo
Published in: European journal of clinical pharmacology (2022)
In our analysis, nearly one-third of octogenarians with AF received an inappropriate dose of DOAC. Several clinical factors were associated with DOACs' overdosage (diabetes mellitus type II, previous bleeding) or underdosage (male gender, coronary artery disease, and higher body mass index). Octogenarians with inappropriate DOACs underdosage showed less survival.
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