HTRA1 promotes EMT through the HDAC6/Ac-α-tubulin pathway in human GBM cells.

Wenbo ZhaoYibo WuShuai WangFeihu ZhaoWenyu LiuZhiyi XueLin ZhangJian WangMingzhi Han Xingang Li Bin Huang

Published in: CNS neuroscience & therapeutics (2024)

Our results indicate that HTRA1 promotes the proliferation and migration of GBM cells in vitro and in vivo, and thus may be a potential target for treatment in gliomas.

Keyphrases

induced apoptosis
cell cycle arrest
endothelial cells
epithelial mesenchymal transition
oxidative stress
high grade
signaling pathway
cell proliferation
combination therapy
smoking cessation