Reconstruction of the gastric cancer microenvironment after neoadjuvant chemotherapy by longitudinal single-cell sequencing.

Yingtai ChenJianhua YinLulu ZhaoGuangyu ZhouShichen DongYueming ZhangPenghui NiuHu RenTianjiao ZhengJuan YanWenbin LiPeiqin MaCuijuan ZhangChen WeiGeorge ChurchGuibo LiDongbing Zhao

Published in: Journal of translational medicine (2022)

In conclusion, our study provided transcriptional profiles of TME between pre-treatment and post-treatment for in-depth understanding on the mechanisms of NACT in gastric cancer and empowering the development of potential optimized therapy procedures and novel drugs.

Keyphrases

neoadjuvant chemotherapy
single cell
stem cells
locally advanced
squamous cell carcinoma
transcription factor
high throughput
combination therapy
climate change
cell therapy
drug induced