A Prospective Longitudinal Investigation of Cortical Thickness and Gyrification in Schizophrenia.
Eric A NelsonNina V KraguljacDavid M WhiteRipu D JindalAh L ShinAdrienne C LahtiPublished in: Canadian journal of psychiatry. Revue canadienne de psychiatrie (2020)
In summary, we report evidence of reduced CT and LGI in unmedicated patients compared to controls, suggesting involvement of different aspects of gray matter morphometry in the pathophysiology of SZ. Importantly, we found that lower CT at baseline and greater increase of CT following 6 weeks of treatment with risperidone were associated with better clinical response. Our results suggest that cortical thinning may normalize as a result of a good response to antipsychotic medication, possibly by alleviating potential neurotoxic processes underlying gray matter deterioration.
Keyphrases
- image quality
- dual energy
- computed tomography
- contrast enhanced
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- bipolar disorder
- positron emission tomography
- prognostic factors
- healthcare
- optical coherence tomography
- peritoneal dialysis
- risk assessment
- patient reported outcomes
- human health
- pet ct