Efficacy of olanzapine, neurokinin-1 receptor antagonists, and thalidomide in combination with palonosetron plus dexamethasone in preventing highly emetogenic chemotherapy-induced nausea and vomiting: a Bayesian network meta-analysis.
Abdullah A AlhifanyAli McBrideAbdulaali R AlmutairiEjaz CheemaAlaa ShahbarYasser AlatawiAdnan S AlharbiHani BabikerKaren MacDonaldMatti AaproIvo AbrahamPublished in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2019)
Based on the data included in the analyses, there is insufficient evidence to support adding thalidomide or NK-1-RA to PALO-DEX in preventing CINV induced by HEC. However, adding olanzapine to PALO-DEX achieves better CR and RNN. Olanzapine side-effects and the absence of direct comparisons explain why some guidelines are cautious in suggesting the use of olanzapine.