Phosphodiesterase inhibitor, Vinpocetine, guards against doxorubicin induced cardiotoxicity via modulation of HIF/VEGF and cGMP/cAMP/SIRT signaling pathways.
Marwa Monier Mahmoud RefaieMaram El-HussienyElshymaa A Abdel-HakeemMichael Atef FawzyEman Shaaban Mahmoud Abd El RahmanSayed ShehataPublished in: Human & experimental toxicology (2022)
We concluded that VIN could ameliorate DOX induced cardiac damage and this effect may be attributed to modulation of HIF/VEGF signaling pathway, up-regulation of cGMP/cAMP/SIRT pathway, inhibition of phosphodiesterase enzyme, besides its anti-apoptotic, anti-inflammatory, and anti-oxidant properties.