Isthmin-1 alleviates cardiac ischemia/reperfusion injury through cGMP-PKG signaling pathway.

Min HuXin ZhangCan HuZhen-Guo MaSha-Sha WangTeng TengXiao-Feng ZengQi-Zhu Tang

Published in: Cardiovascular research (2024)

ISM1 can protect against cardiac I/R injury through cGMP-PKG signaling pathway, and it is a promising therapeutic and predictive target of cardiac I/R injury.

Keyphrases

signaling pathway
ischemia reperfusion injury
left ventricular
nitric oxide
pi k akt
oxidative stress
heart failure
cell proliferation
mouse model