Inhibition of HDAC6 promotes microvascular endothelial cells to phagocytize myelin debris and reduces inflammatory response to accelerate the repair of spinal cord injury.

Chengjie WuYalan PanLining WangMengmin LiuPengcheng TuSixian ChenLei ShiDanqing YanYong MaYang Guo

Published in: CNS neuroscience & therapeutics (2023)

Inhibition of HDAC6 to regulate the immune-inflammatory response and promote MECs to phagocytize myelin debris may represent a novel strategy in the treatment of SCI.

Keyphrases

spinal cord injury
inflammatory response
endothelial cells
histone deacetylase
white matter
spinal cord
neuropathic pain
lipopolysaccharide induced
lps induced
toll like receptor
high glucose
combination therapy
replacement therapy
vascular endothelial growth factor
smoking cessation