Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET).
Emmanuel WeissCarlos de la Peña-RamirezFerran AguilarJuan-Jose LozanoCristina Sánchez-GarridoPatricia SierraPedro Izquierdo-Bueno MartinJuan Manuel DiazFrançois FenailleFlorence A CastelliThierry GustotWim LalemanAgustín Albillos MartínezCarlo AlessandriaMarco DomenicaliPaolo CaraceniSalvatore PianoFaouzi SalibaStefan ZeuzemAlexander L GerbesJulia A WendonChristian JansenWenyi GuMaria PappRaj MookerjeeCarmine Gabriele GambinoCesar JiménezIlaria GiovoGiacomo ZaccheriniManuela MerliAntonella PutignanoFrank Erhard UschnerThomas BergKaren SchmidtChristian TrautweinAlexander ZipprichRafael BañaresJosé PresaJoan GenescaVictor VargasJavier FernándezMauro BernardiPaolo AngeliRajiv JalanJoan ClariaChristophe JunotRichard MoreauJonel TrebickaVicente ArroyoPublished in: Gut (2023)
Models including metabolites (CLIF-C MET) reflecting SI, mitochondrial dysfunction and sympathetic system activation are better predictors of short-term mortality than scores based only on organ dysfunction (eg, MELDNa), especially in patients with ACLF.