Air pollution as a contributor to the inflammatory activity of multiple sclerosis.
Andreas CorteseLuca LovaPatrizia ComoliElisabetta VolpeSilvia VillaGiulia MallucciSabrina La SalviaAlfredo RomaniDiego FranciottaValentina BollatiSabrina BassoIlaria GuidoGiuseppe QuartuccioLuca BattistiniCristina CeredaRoberto BergamaschiPublished in: Journal of neuroinflammation (2020)
Ex vivo and in vitro studies support the pro-inflammatory role of PM in MS, by upregulating expression of CCR6 on circulating CD4+ T cells and inducing in innate immune cells the production of Th17 polarizing cytokines. Therefore, we speculate that in MS respiratory exposure to PM10 may induce the production in the lung of autoreactive Th17 lymphocytes and boost their migratory properties through the blood-brain barrier.
Keyphrases
- water soluble
- multiple sclerosis
- air pollution
- mass spectrometry
- immune response
- particulate matter
- ms ms
- white matter
- peripheral blood
- oxidative stress
- lung function
- regulatory t cells
- risk assessment
- binding protein
- cystic fibrosis
- heavy metals
- respiratory tract
- chronic obstructive pulmonary disease
- polycyclic aromatic hydrocarbons