Deep brain stimulation of the anterior nuclei of the thalamus relieves basal ganglia dysfunction in monkeys with temporal lobe epilepsy.

Tingting DuYingchuan ChenLin ShiDefeng LiuYuye LiuTianshuo YuanXin ZhangGuanyu ZhuJian-Guo Zhang

Published in: CNS neuroscience & therapeutics (2020)

ANT-DBS exerts neuroprotective effects on the caudate and putamen, enhances D1 and D2 receptor expression, and downregulates GPi overactivation, which enhanced the antiepileptic function of the basal ganglia.

Keyphrases

deep brain stimulation
temporal lobe epilepsy
parkinson disease
obsessive compulsive disorder
oxidative stress
cerebral ischemia
blood brain barrier