Evolution of thyroid cancer biomarkers: from laboratory test to patients' clinical management.
Maria Luisa GaroAlfredo CampennìPetra Petranovic-OvcaricekFederica D'AurizioLuca M GiovanellaPublished in: Clinical chemistry and laboratory medicine (2022)
Over the past three decades, laboratory medicine has significantly evolved thanks to technological advances made possible by new materials and evidence. Clinicians' ongoing requests for powerful, rapid, and minimally invasive tests has led manufacturers to develop rapid, accurate, and sensitive tests that can increase diagnostic accuracy and improve follow-up, bringing laboratory medicine ever closer to personalized medicine. The aim of this study was to critically review the main problems of the current Tg and CT biomarkers for the diagnosis/monitoring of DTC and MTC, respectively, and to identify the advantages and challenges of using the new laboratory biomarkers in the clinical management of patients with differentiated and medullary thyroid cancer. Insufficient harmonization of Tg and CT assays and lack of interchangeability of laboratory results and cutoff values pose challenges for comparability and standardization of procedures and methods. New diagnostic and monitoring approaches such as PCT or the Tg doubling time have proven to be effective. Close collaboration between clinicians and laboratory specialists remains essential to translate the advantages and limitations of current assays into appropriate clinical interpretation criteria. Over the years, the journal Clinical Chemistry and Laboratory Medicine ( CCLM ) has taken many steps to develop advanced research and technology in the diagnosis and monitoring of tumor cancer and to help clinicians translate it into clinical practice.
Keyphrases
- minimally invasive
- palliative care
- clinical practice
- computed tomography
- ejection fraction
- end stage renal disease
- mental health
- magnetic resonance imaging
- magnetic resonance
- contrast enhanced
- prognostic factors
- image quality
- squamous cell carcinoma
- positron emission tomography
- quantum dots
- loop mediated isothermal amplification
- patient reported outcomes
- patient reported