Effect of Occlusion Site on the Safety and Efficacy of Intravenous Alteplase Before Endovascular Thrombectomy: A Prespecified Subgroup Analysis of DIRECT-MT.
Yu ZhouPengfei XingZifu LiXiaoxi ZhangLei ZhangYongxin ZhangYongwei ZhangBo HongYi XuQinghai HuangQiang LiKaijun ZhaoChao ZouYing YuQiao ZuoSheng LiuLiyong ZhangCharles B L M MajoieYvo B W E M RoosK M TreurnietXiaofei YeYa PengPengfei YangJianmin Liunull nullPublished in: Stroke (2021)
In this prespecified subgroup of a randomized trial, we found no evidence that occlusion location can inform intravenous alteplase decisions in endovascular treatment eligible patients directly presenting at endovascular treatment capable centers. Future studies are needed to confirm our findings. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03469206.