Increased apoptosis and peripheral blood mononuclear cell suppression of bone marrow mesenchymal stem cells in severe aplastic anemia.
Yu-Hua ChaoChiao-Wen LinHui-Hsien PanShun-Fa YangTe-Fu WengChing-Tien PengKang-Hsi WuPublished in: Pediatric blood & cancer (2018)
Our data revealed increased apoptosis and PBMC suppression of SAA MSCs. The alterations of MSCs may contribute to the formation of functionally abnormal microenvironments in SAA BM.
Keyphrases
- peripheral blood
- mesenchymal stem cells
- endoplasmic reticulum stress
- oxidative stress
- cell cycle arrest
- single cell
- cell death
- umbilical cord
- cell therapy
- chronic kidney disease
- electronic health record
- allogeneic hematopoietic stem cell transplantation
- big data
- machine learning
- iron deficiency
- stem cells
- pi k akt
- acute lymphoblastic leukemia
- acute myeloid leukemia
- bone marrow