Liquid BIOpsy for MiNimal RESidual DiSease Detection in Head and Neck Squamous Cell Carcinoma (LIONESS)-a personalised circulating tumour DNA analysis in head and neck squamous cell carcinoma.

Susanne FlachKaren HowarthSophie HackingerChristodoulos PipinikasPete EllisKirsten McLayGiovanni MarsicoTim ForshewChristoph WalzChristoph A ReichelOlivier GiresMartin CanisPhilipp Baumeister

Published in: British journal of cancer (2022)

This study illustrates the potential of ctDNA as a biomarker for detecting minimal residual disease and recurrence in HNSCC and demonstrates the feasibility of personalised ctDNA assays for the detection of disease prior to clinical recurrence.

Keyphrases

circulating tumor
loop mediated isothermal amplification
real time pcr
free survival
label free
circulating tumor cells
high throughput
risk assessment
human health
sensitive detection
nucleic acid