Different qualifiers of AUS/FLUS thyroid FNA have distinct BRAF, RAS, RET/PTC, and PAX8/PPARg alterations.

Claudio BellevicineRoberta SgarigliaIlaria MigliaticoElena VigliarMelania D'AnnaMaria Antonia NacchioNicola SerraUmberto MalapelleMassimo Bongiovanni Giancarlo Troncone

Published in: Cancer cytopathology (2018)

BRAF and RAS mutations are associated with different AUS/FLUS qualifiers and hence have different risks of malignancy. Consequently, a hybrid molecular and morphological subcategorization system could improve the malignancy risk stratification of thyroid FNA samples diagnosed as AUS/FLUS. Cancer Cytopathol 2018;126:317-25. © 2018 American Cancer Society.

Keyphrases

wild type
papillary thyroid
squamous cell
squamous cell carcinoma
fine needle aspiration
metastatic colorectal cancer
risk assessment
climate change
human health