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Risk factors for thiopurine-induced myelosuppression and infections in inflammatory bowel disease patients with a normal TPMT genotype.

M M T J BroekmanM J H CoenenG J WantenC J van MarrewijkO H KlungelA L M VerbeekP M HooymansH-J GuchelaarH SchefferL J J DerijksDennis R WongD J de Jong
Published in: Alimentary pharmacology & therapeutics (2017)
Low baseline WBC count and mercaptopurine, due to a relatively higher dose, were risk factors for thiopurine-induced leucopenia in patients without a TPMT variant.
Keyphrases
  • high glucose
  • end stage renal disease
  • diabetic rats
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • peritoneal dialysis
  • oxidative stress
  • endothelial cells
  • peripheral blood