Electrochemical and Scalable Dehydrogenative C(sp3 )-H Amination via Remote Hydrogen Atom Transfer in Batch and Continuous Flow.

A hydrogen atom transfer-directed electrochemical intramolecular C-H amination has been developed in which the N-radical species are generated at the anode, and the base required for the reaction is generated at the cathode. A broad range of valuable pyrrolidines were prepared in good yields and with high chemoselectivity. The reaction was easily scaled up in both batch and continuous flow systems.