Protein signatures of molecular pathways in non-small cell lung carcinoma (NSCLC): comparison of glycoproteomics and global proteomics.
Shuang YangLijun ChenDaniel W ChanQing Kay LiHui ZhangPublished in: Clinical proteomics (2017)
Our systematic analysis of proteins and glycoproteins demonstrates changes of protein and glycoprotein relative abundance in SqCC (TP53, U2AF1, and RXR) and in ADC (SMARCA4, NOTCH1, PTEN, and MST1). Among them, eleven glycoproteins were upregulated in both ADC and SqCC. Two glycoproteins (ELANE and IGFBP3) were only increased in SqCC, and six glycoproteins (ACAN, LAMC2, THBS1, LTBP1, PSAP and COL1A2) were increased in ADC. Ingenuity Pathway Analysis (IPA) showed that several crucial pathways were activated in SqCC and ADC tumor tissues.
Keyphrases
- diffusion weighted imaging
- diffusion weighted
- contrast enhanced
- small cell lung cancer
- cell proliferation
- mass spectrometry
- gene expression
- magnetic resonance imaging
- protein protein
- single cell
- amino acid
- binding protein
- cell therapy
- atrial fibrillation
- stem cells
- computed tomography
- mesenchymal stem cells
- bone marrow
- single molecule
- label free
- anaerobic digestion