Protective effect of Galectin-3 inhibitor against cardiac remodelling in an isoprenaline-induced myocardial infarction in type 2 diabetes.
Manal Moustafa MahmoudMai Mohammed HassanHany El-Sebaee ElsayedAmal E FaresMona M SaberLaila Ahmed RashedOmaima Mohammed AbdelwahedPublished in: Archives of physiology and biochemistry (2024)
Type 2 Diabetes mellitus (T2DM) has the potential to impair cardiac function and cause heart failure. We aimed to study the cardioprotective influence of Galactin-3 (Gal-3) inhibitor; modified citrus pectin (MCP) in isoprenaline induced myocardial infarction (MI) in T2DM rats. Forty rats were allocated into 4 groups; groups I and II served as control. T2DM was provoked in groups III and IV by serving them high fat diet followed by a single low dose of Streptozotocin (STZ), then group IV were administered MCP in drinking water for 6 weeks. Groups III and IV were then subcutaneously injected isoprenaline hydrochloride once daily on the last 2 successive days to induce MI. MCP restored echocardiographic parameters with significant decline in Gal-3 area % in cardiac tissue alongside protection against cardiac remodelling. our data showed that there is a protective potential for Gal-3 inhibitor (MCP) against cardiac injury in isoprenaline induced MI in T2DM.
Keyphrases
- left ventricular
- diabetic rats
- high fat diet
- heart failure
- drinking water
- type diabetes
- glycemic control
- high glucose
- low dose
- oxidative stress
- insulin resistance
- adipose tissue
- high dose
- physical activity
- left atrial
- pulmonary hypertension
- mitral valve
- electronic health record
- skeletal muscle
- cardiovascular disease
- risk assessment
- climate change
- stress induced