Exposure-safety and efficacy response relationships and population pharmacokinetics of eslicarbazepine acetate.

Barry E GidalM P JacobsonE Ben-MenachemM CarreñoD BlumP Soares-da-SilvaA FalcãoF RochaJ MoreiraT GrinnellE LudwigJ Fiedler-KellyJ PassarellS Sunkaraneni

Published in: Acta neurologica Scandinavica (2018)

Pharmacokinetic and PK/PD modeling were implemented during the development of ESL for adjunctive treatment of FOS in adults. This quantitative approach supported decision-making during the development of ESL, and contributed to dosing recommendations and labeling information related to drug interactions.

Keyphrases

decision making
high resolution
healthcare
clinical practice
mass spectrometry
combination therapy
smoking cessation
replacement therapy