Preparation, chemical characterization and determination of crocetin's pharmacokinetics after oral and intravenous administration of saffron (Crocus sativus L.) aqueous extract to C57/BL6J mice.

Eirini ChristodoulouMaria-Eleni GrafakouEleni SkaltsaNikolaos KadoglouNikolaos KostomitsopoulosGeorgia Valsami

Published in: The Journal of pharmacy and pharmacology (2018)

SFE is a stable lyophilized extract rich in all-trans-crocin. The PK study allowed the estimation of basic PK parameters and the bioavailability of SFE's main bioactive component, crocetin, after peros administration.

Keyphrases

oxidative stress
molecularly imprinted
anti inflammatory
high dose
type diabetes
high fat diet induced
ionic liquid
solid phase extraction
metabolic syndrome
low dose
skeletal muscle
insulin resistance
liquid chromatography