Polycomb group genes are required for neuronal pruning in Drosophila.

Shufeng BuSamuel Song Yuan LauWei Lin YongHeng ZhangSasinthiran ThiagarajanArash BashirullahFengwei Yu

Published in: BMC biology (2023)

This study demonstrates important roles of PcG and Hox genes in regulating ecdysone signalling and neuronal pruning in Drosophila. Moreover, our findings suggest a non-canonical and PRC2-independent role of PRC1 in Hox gene silencing during neuronal pruning.

Keyphrases

genome wide
cerebral ischemia
dna methylation
gene expression
transcription factor