Cyclic thrombocytopenia associated with estradiol: a case report.

Ningbo PangYingwei LiKangxi ZhouChunliang LiuRong YanChenglin SunWeiling XiaoChanggeng RuanZhimin ZhaiKesheng Dai

Published in: Hematology (Amsterdam, Netherlands) (2023)

We find that E2 induces platelet apoptosis and clearance through PDE3A-mediated PKA inhibition. Activation of PKA rescues E2-induced thrombocytopenia in mice. Thus, our study reveals a pathogenesis of E2-related CTP and suggests promising therapeutic strategies for the disease.

Keyphrases

oxidative stress
high glucose
diabetic rats
endoplasmic reticulum stress
mouse model
cell death
drug induced
high fat diet induced
type diabetes
adipose tissue
cell proliferation
endothelial cells
wild type