Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles - A Mendelian randomization analysis.
Anna HelgadottirGudmar ThorleifssonAudunn SnaebjarnarsonLilja StefansdottirGardar SveinbjörnssonVinicius TraganteEyþór BjörnssonValgerdur SteinthorsdottirSolveig GretarsdottirHannes HelgasonJona SaemundsdottirIsleifur OlafssonJens Jakob ThuneAnna Axelsson RajaJonas GhouseMorten Salling OlesenAlex ChristensenRikke Louise JacobsenJoseph DowsettMie Topholm BruunKaspar NielsenKirk U KnowltonLincoln NadauldRafn BenediktssonChristian ErikstrupOle B PedersenKarina BanasikSøren Brunaknull nullHenning BundgaardSisse R OstrowskiPatrick SulemDavid O ArnarGudmundur ThorgeirssonUnnur ThorsteinsdottirDaniel F GudbjartssonKari StefanssonHilma HólmPublished in: European journal of preventive cardiology (2022)
Many sequence variants have discordant effects on non-HDL-C and apoB. These variants allowed us to show that the causal mechanism underlying the relationship between apolipoprotein B particles and CAD is more associated with non-HDL-C than apoB particle concentration.