Maternal Exposure to Ethanol During Pregnancy and Lactation Affects Glutamatergic System and Induces Oxidative Stress in Offspring Hippocampus.
Patricia A CesconettoCamila M AndradeDaiane CattaniJuliana T DominguesEduardo B ParisottoDanilo W FilhoAriane Zamoner Pacheco de SouzaPublished in: Alcoholism, clinical and experimental research (2016)
The decline in glucose transport coincided with increased lactate dehydrogenase activity, suggesting an adaptative response in EtOH-exposed offspring hippocampus, using lactate as an alternative fuel. These events were associated with oxidative damage, as demonstrated by changes in the enzymatic antioxidant defense system and lipid peroxidation. Taken together, the results demonstrate that maternal exposure to EtOH during pregnancy and lactation impairs glutamatergic transmission, as well as inducing oxidative stress and energy deficit in immature rat hippocampus.
Keyphrases
- oxidative stress
- prefrontal cortex
- high fat diet
- dairy cows
- cerebral ischemia
- human milk
- birth weight
- diabetic rats
- dna damage
- ischemia reperfusion injury
- cognitive impairment
- induced apoptosis
- pregnancy outcomes
- hydrogen peroxide
- blood glucose
- blood pressure
- brain injury
- heat shock
- adipose tissue
- anti inflammatory
- body mass index
- gestational age
- nitric oxide
- preterm infants
- signaling pathway
- heat stress