Serious adverse drug reactions at two children's hospitals in South Africa.

Johannes P MoutonMelony C Fortuin-de SmidtNicole JobanputraUshma MehtaAnnemie StewartReneé de WaalKarl-Günter TechnauAndrew ArgentMax KroonChristiaan ScottKaren Cohen

Published in: BMC pediatrics (2020)

Serious ADR prevalence in our survey was similar to the prevalence found elsewhere. In our setting, serious ADRs were associated with HIV-infection and the antiviral drug class was one of the most commonly implicated. Similar to other sub-Saharan African studies, a large proportion of serious ADRs were fatal or near-fatal. Many serious ADRs were preventable.

Keyphrases

adverse drug
south africa
risk factors
electronic health record
emergency department
drug induced
young adults
healthcare
antiretroviral therapy
case control