Large-scale sequencing studies expand the known genetic architecture of Alzheimer's disease.

Diane XueWilliam S BushAlan E RentonEdoardo A MarcoraJoshua C BisBrian W Kunklenull nullEric BoerwinkleAnita L DeStefanoLindsay FarrerAlison GoateRichard MayeuxMargaret Pericak-VanceGerard SchellenbergSudha SeshadriEllen WijsmanJonathan L HainesElizabeth E Blue

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2021)

Alternative study designs provide unique insights into AD genetics. Shared pathways enriched by different genes highlight their relevance to AD pathogenesis, while the patterns of pathway enrichment unique to each gene set provide additional targets for functional studies.

Keyphrases

genome wide
case control
copy number
genome wide identification
dna methylation
single cell
gene expression
genome wide analysis
transcription factor