A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups.

Yuanbing JiangHyebin UhmFanny C IpLi OuyangRonnie M N LoElaine Y L ChengXiaoyun CaoClara M C TanBrian C H LawPaula Ortiz-RomeroAlbert Puig-PijoanAida Fernández-LebreroJosé ContadorKin Y MokJohn HardyTimothy C Y KwokVincent C T MokMarc Suárez-CalvetHenrik ZetterbergAmy K Y FuNancy Y Ip

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

The authors developed a blood-based biomarker assay for Alzheimer's disease. The 21-protein assay classifies AD/MCI and indicates brain amyloid pathology. The 21-protein assay can simultaneously assess activities of five biological processes. Ethnic-specific dysregulations of biological processes in AD were revealed.

Keyphrases

high throughput
cognitive decline
lymph node
mild cognitive impairment
single cell
protein protein
binding protein
small molecule
pet ct
blood brain barrier