Wnt/β-catenin plays a dual function in calcium hydroxide induced proliferation, migration, osteogenic differentiation and mineralization in vitro human dental pulp stem cells.
Yu LiuNan LiuJing NaChiyu LiGan YueYu-Bo FanLisha ZhengPublished in: International endodontic journal (2022)
Wnt/β-catenin pathway plays a dual role in calcium hydroxide-regulated DPSC behaviour. Incubation with calcium hydroxide promoted rapid proliferation and migration of DPSCs, while prolonged incubation negatively regulated osteogenic differentiation and mineralization.
Keyphrases
- stem cells
- cell proliferation
- mesenchymal stem cells
- bone marrow
- endothelial cells
- reduced graphene oxide
- transcription factor
- high glucose
- aqueous solution
- epithelial mesenchymal transition
- diabetic rats
- signaling pathway
- induced pluripotent stem cells
- drug induced
- oxidative stress
- loop mediated isothermal amplification
- quantum dots