Sleep Modulation Alleviates Axonal Damage and Cognitive Decline after Rodent Traumatic Brain Injury.
Marta M MorawskaFabian BücheleCarlos Goncalves MoreiraLukas L ImbachDaniela NoainChristian R BaumannPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)
Traumatic brain injury (TBI) is a clinically important entity. Cognitive deficits belong to the most prevalent chronic posttraumatic symptoms, most likely due to diffuse axonal injury (DAI). A growing body of evidence suggests a role of sleep in the clearance of waste products in the brain, possibly including amyloid precursor protein (APP), a marker of DAI. In this study, we provide evidence that enhancement of slow-wave oscillatory activity in the delta-frequency range decreases the APP-immunoreactivity and preserves cognitive abilities after trauma, potentially offering novel, noninvasive treatment options for traumatic injury.
Keyphrases
- traumatic brain injury
- cognitive decline
- spinal cord injury
- sleep quality
- mild cognitive impairment
- physical activity
- severe traumatic brain injury
- oxidative stress
- heavy metals
- high frequency
- low grade
- binding protein
- depressive symptoms
- amino acid
- mouse model
- protein protein
- optic nerve
- sewage sludge
- subarachnoid hemorrhage
- multiple sclerosis
- municipal solid waste
- anaerobic digestion