Plasma and memory B cell responses targeting O-specific polysaccharide (OSP) are associated with protection against Vibrio cholerae O1 infection among household contacts of cholera patients in Bangladesh.
Amena AktarM Arifur RahmanSadia AfrinAklima AkterTaher UddinTahirah YasminMd Israk Nur SamiPinki DashSultana Rownok JahanFahima ChowdhuryAshraful I KhanRegina C LaRocqueRichelle C CharlesTaufiqur Rahman BhuiyanAnjali MandlikMeagan KellyPavol KováčPeng XuStephen B CalderwoodJason B HarrisFirdausi QadriEdward T RyanPublished in: PLoS neglected tropical diseases (2018)
These results suggest that immune responses that target OSP, both in plasma and memory responses, may be important in mediating protection against infection with V. cholerae O1.