Hippocampal amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid GluA1 (AMPA GluA1) receptor subunit involves in learning and memory improvement following treatment with Centella asiatica extract in adolescent rats.
Nor Aqilah Binti Mohd Yusuf YeoJafri Malin AbdullahJia Hui WongFaruque Reza MohammedMohd Harizal SenikJingli ZhangSiti Rafidah YusofHasnan JaafarMohd Llham AdenanHabsah MohamadTengku Sifzizul Tengku MuhammadJafri Malin AbdullahPublished in: Brain and behavior (2018)
The C. asiatica extract therefore improved hippocampus-dependent spatial learning and memory in a dose-dependent manner in rats through the GluA1-containing AMPA receptor in the CA1 and CA2 sub regions of the hippocampus.